# San Francisco 49ers v Denver Broncos — NFL Week 4 2026 AI Prediction by Alphr

## Prediction coming soon

Our NFL model publishes its win probability, margin and total for San Francisco 49ers v Denver Broncos closer to kick-off. The head-to-head picture below is real historical data.

### San Francisco 49ers v Denver Broncos
Mon, 05 Oct, 07:25 am AEDT · Levi's Stadium · Week 4

### Match Preview

**San Francisco 49ers vs Denver Broncos Prediction & Tips | NFL Week 4 2026**

**By the numbers**

|  |  |
|---|---|
| H2H (last 7) | San Francisco 49ers 3 · Denver Broncos 4 |
| Last meeting | Denver Broncos 11-10 (2022) |
| San Francisco 49ers 2026 so far | 3-0 · 2-0 home |
| San Francisco 49ers scoring | 32.7 for · 16.7 against |
| Denver Broncos 2026 so far | 2-1 · 0-1 away |
| Denver Broncos scoring | 20.0 for · 23.3 against |
| Quarterbacks | Brock Purdy · Bo Nix |
| Head coaches | Kyle Shanahan · Sean Payton |
| Market | San Francisco 49ers $1.74 · Denver Broncos $2.14 |
| Spread | San Francisco 49ers -2.5 · total 46.5 |

_Pre-match read · Alphr model_

### H2H History (Last 5) — San Francisco 49ers lead 3-2

| Season | Round | Home | Score | Away |
|---|---|---|---|---|
| 2022 | W3 | Denver Broncos | 11 – 10 | San Francisco 49ers |
| 2018 | W14 | San Francisco 49ers | 20 – 14 | Denver Broncos |
| 2014 | W7 | Denver Broncos | 42 – 17 | San Francisco 49ers |
| 2010 | W8 | San Francisco 49ers | 24 – 16 | Denver Broncos |
| 2006 | W17 | Denver Broncos | 23 – 26 | San Francisco 49ers |

**Prediction by Alphr** (https://alphr.com.au) — free AI predictions for every AFL, NRL & Super League match, published before kick-off and never edited. Verified track record: https://alphr.com.au/accuracy

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Canonical URL: https://alphr.com.au/nfl/match/2026-r4-san-francisco-49ers-v-denver-broncos
RSS feed: https://alphr.com.au/feed.xml
Prediction JSON API: today https://alphr.com.au/api/predictions/today · this week https://alphr.com.au/api/predictions/weekly
Markdown view for AI agents. Machine-readable index: https://alphr.com.au/llms.txt · full reference: https://alphr.com.au/llms-full.txt
All predictions are published before kick-off and verified after full time. Free, no login. 18+ gamble responsibly (AU).
Last updated: 2026-09-29 15:12 UTC