# NFL Week 16 2025 Predictions & Tips — Alphr

> Free AI NFL predictions for Week 16 of the 2025 season — 16 matches, every head-to-head, line, margin and totals pick published before kick-off and verified after full time. Quote with attribution to Alphr (alphr.com.au).

## Week 16 at a glance
- 16 matches · 27W–21L on 48 settled picks (56% strike rate) · best value +28.8% edge

## Week 16 predictions

| Match | Model pick | Win prob | Result |
|---|---|---|---|
| Seattle Seahawks v Los Angeles Rams | Los Angeles Rams @ $2.02 | Los Angeles Rams 53% | LOST |
| Washington Commanders v Philadelphia Eagles | Philadelphia Eagles @ $1.26 | Philadelphia Eagles 68% | WON |
| Chicago Bears v Green Bay Packers | Green Bay Packers @ $1.98 | Green Bay Packers 63% | LOST |
| Carolina Panthers v Tampa Bay Buccaneers | Tampa Bay Buccaneers @ $1.65 | Tampa Bay Buccaneers 54% | LOST |
| Cleveland Browns v Buffalo Bills | Buffalo Bills @ $1.17 | Buffalo Bills 53% | WON |
| Dallas Cowboys v Los Angeles Chargers | Los Angeles Chargers @ $2.02 | Los Angeles Chargers 60% | WON |
| Miami Dolphins v Cincinnati Bengals | Cincinnati Bengals @ $1.49 | Cincinnati Bengals 84% | WON |
| New Orleans Saints v New York Jets | New Orleans Saints @ $1.34 | New Orleans Saints 87% | WON |
| New York Giants v Minnesota Vikings | Minnesota Vikings @ $1.68 | Minnesota Vikings 88% | WON |
| Tennessee Titans v Kansas City Chiefs | Kansas City Chiefs @ $1.54 | Kansas City Chiefs 78% | LOST |
| Arizona Cardinals v Atlanta Falcons | Atlanta Falcons @ $1.68 | Atlanta Falcons 78% | WON |
| Denver Broncos v Jacksonville Jaguars | Denver Broncos @ $1.57 | Denver Broncos 66% | LOST |
| Detroit Lions v Pittsburgh Steelers | Detroit Lions @ $1.24 | Detroit Lions 78% | LOST |
| Houston Texans v Las Vegas Raiders | Houston Texans @ $1.06 | Houston Texans 95% | WON |
| Baltimore Ravens v New England Patriots | New England Patriots @ $2.54 | New England Patriots 63% | WON |
| Indianapolis Colts v San Francisco 49ers | San Francisco 49ers @ $1.44 | San Francisco 49ers 87% | WON |

## Match-by-match

### Seattle Seahawks v Los Angeles Rams
Fri, 19 Dec, 12:15 pm AEDT · Lumen Field · Week 16
Alphr AI win probability: Seattle Seahawks 46.9% / Los Angeles Rams 53.1%
- **Head to Head:** Los Angeles Rams to win @ $2.02 (edge +3.6%) — model probability 53.1% — result: LOST
- **Line / Spread:** Los Angeles Rams +1.5 @ $1.91 (edge +0.0%) — result: WON
- **Total (Over/Under):** Under 42.5 @ $1.91 (edge +0.0%) — result: LOST
- Predicted margin: Seattle Seahawks by 2 · Predicted total: 39
Full breakdown: https://alphr.com.au/nfl/match/2025-r16-seattle-seahawks-v-los-angeles-rams

### Washington Commanders v Philadelphia Eagles
Sun, 21 Dec, 09:00 am AEDT · FedExField · Week 16
Alphr AI win probability: Washington Commanders 31.7% / Philadelphia Eagles 68.3%
- **Head to Head:** Philadelphia Eagles to win @ $1.26 (edge -10.9%) — model probability 68.3% — result: WON
- **Line / Spread:** Washington Commanders +7 @ $1.91 (edge +0.0%) — result: LOST
- **Total (Over/Under):** Under 43.5 @ $1.91 (edge +0.0%) — result: LOST
- Predicted margin: Philadelphia Eagles by 8 · Predicted total: 43
Full breakdown: https://alphr.com.au/nfl/match/2025-r16-washington-commanders-v-philadelphia-eagles

### Chicago Bears v Green Bay Packers
Sun, 21 Dec, 12:20 pm AEDT · Soldier Field · Week 16
Alphr AI win probability: Chicago Bears 36.5% / Green Bay Packers 63.5%
- **Head to Head:** Green Bay Packers to win @ $1.98 (edge +13.0%) — model probability 63.5% — result: LOST
- **Line / Spread:** Green Bay Packers +1.5 @ $1.91 (edge +0.0%) — result: LOST
- **Total (Over/Under):** Over 45.5 @ $1.91 (edge +0.0%) — result: LOST
- Predicted margin: Chicago Bears by 1 · Predicted total: 50
Full breakdown: https://alphr.com.au/nfl/match/2025-r16-chicago-bears-v-green-bay-packers

### Carolina Panthers v Tampa Bay Buccaneers
Mon, 22 Dec, 05:00 am AEDT · Bank of America Stadium · Week 16
Alphr AI win probability: Carolina Panthers 45.8% / Tampa Bay Buccaneers 54.2%
- **Head to Head:** Tampa Bay Buccaneers to win @ $1.65 (edge -6.6%) — model probability 54.2% — result: LOST
- **Line / Spread:** Tampa Bay Buccaneers -3 @ $1.91 (edge +0.0%) — result: LOST
- **Total (Over/Under):** Under 44.5 @ $1.91 (edge +0.0%) — result: WON
- Predicted margin: Tampa Bay Buccaneers by 3 · Predicted total: 42
Full breakdown: https://alphr.com.au/nfl/match/2025-r16-carolina-panthers-v-tampa-bay-buccaneers

### Cleveland Browns v Buffalo Bills
Mon, 22 Dec, 05:00 am AEDT · FirstEnergy Stadium · Week 16
Alphr AI win probability: Cleveland Browns 47.4% / Buffalo Bills 52.6%
- **Head to Head:** Buffalo Bills to win @ $1.17 (edge -32.6%) — model probability 52.6% — result: WON
- **Line / Spread:** Cleveland Browns +10.5 @ $1.91 (edge +0.0%) — result: WON
- **Total (Over/Under):** Over 41.5 @ $1.91 (edge +0.0%) — result: WON
- Predicted margin: Buffalo Bills by 5 · Predicted total: 43
Full breakdown: https://alphr.com.au/nfl/match/2025-r16-cleveland-browns-v-buffalo-bills

### Dallas Cowboys v Los Angeles Chargers
Mon, 22 Dec, 05:00 am AEDT · AT&T Stadium · Week 16
Alphr AI win probability: Dallas Cowboys 39.6% / Los Angeles Chargers 60.4%
- **Head to Head:** Los Angeles Chargers to win @ $2.02 (edge +10.9%) — model probability 60.4% — result: WON
- **Line / Spread:** Los Angeles Chargers +1.5 @ $1.91 (edge +0.0%) — result: WON
- **Total (Over/Under):** Over 50.5 @ $1.91 (edge +0.0%) — result: WON
- Predicted margin: Dallas Cowboys by 4 · Predicted total: 54
Full breakdown: https://alphr.com.au/nfl/match/2025-r16-dallas-cowboys-v-los-angeles-chargers

### Miami Dolphins v Cincinnati Bengals
Mon, 22 Dec, 05:00 am AEDT · Hard Rock Stadium · Week 16
Alphr AI win probability: Miami Dolphins 16.0% / Cincinnati Bengals 84.0%
- **Head to Head:** Cincinnati Bengals to win @ $1.49 (edge +16.8%) — model probability 84.0% — result: WON
- **Line / Spread:** Miami Dolphins +3.5 @ $1.91 (edge +0.0%) — result: LOST
- **Total (Over/Under):** Over 48.5 @ $1.91 (edge +0.0%) — result: WON
- Predicted margin: Miami Dolphins by 0 · Predicted total: 49
Full breakdown: https://alphr.com.au/nfl/match/2025-r16-miami-dolphins-v-cincinnati-bengals

### New Orleans Saints v New York Jets
Mon, 22 Dec, 05:00 am AEDT · Mercedes-Benz Superdome · Week 16
Alphr AI win probability: New Orleans Saints 87.0% / New York Jets 13.0%
- **Head to Head:** New Orleans Saints to win @ $1.34 (edge +12.1%) — model probability 87.0% — result: WON
- **Line / Spread:** New York Jets +6.5 @ $1.91 (edge +0.0%) — result: LOST
- **Total (Over/Under):** Under 39.5 @ $1.91 (edge +0.0%) — result: WON
- Predicted margin: New Orleans Saints by 7 · Predicted total: 38
Full breakdown: https://alphr.com.au/nfl/match/2025-r16-new-orleans-saints-v-new-york-jets

### New York Giants v Minnesota Vikings
Mon, 22 Dec, 05:00 am AEDT · MetLife Stadium · Week 16
Alphr AI win probability: New York Giants 11.5% / Minnesota Vikings 88.5%
- **Head to Head:** Minnesota Vikings to win @ $1.68 (edge +28.8%) — model probability 88.5% — result: WON
- **Line / Spread:** Minnesota Vikings -2.5 @ $1.91 (edge +0.0%) — result: WON
- **Total (Over/Under):** Over 41.5 @ $1.91 (edge +0.0%) — result: LOST
- Predicted margin: Minnesota Vikings by 9 · Predicted total: 46
Full breakdown: https://alphr.com.au/nfl/match/2025-r16-new-york-giants-v-minnesota-vikings

### Tennessee Titans v Kansas City Chiefs
Mon, 22 Dec, 05:00 am AEDT · Nissan Stadium · Week 16
Alphr AI win probability: Tennessee Titans 21.9% / Kansas City Chiefs 78.1%
- **Head to Head:** Kansas City Chiefs to win @ $1.54 (edge +13.2%) — model probability 78.1% — result: LOST
- **Line / Spread:** Kansas City Chiefs -3.5 @ $1.91 (edge +0.0%) — result: LOST
- **Total (Over/Under):** Over 37.5 @ $1.91 (edge +0.0%) — result: LOST
- Predicted margin: Kansas City Chiefs by 6 · Predicted total: 38
Full breakdown: https://alphr.com.au/nfl/match/2025-r16-tennessee-titans-v-kansas-city-chiefs

### Arizona Cardinals v Atlanta Falcons
Mon, 22 Dec, 08:05 am AEDT · State Farm Stadium · Week 16
Alphr AI win probability: Arizona Cardinals 22.3% / Atlanta Falcons 77.7%
- **Head to Head:** Atlanta Falcons to win @ $1.68 (edge +18.0%) — model probability 77.7% — result: WON
- **Line / Spread:** Atlanta Falcons -2.5 @ $1.91 (edge +0.0%) — result: WON
- **Total (Over/Under):** Under 48.5 @ $1.91 (edge +0.0%) — result: WON
- Predicted margin: Atlanta Falcons by 9 · Predicted total: 42
Full breakdown: https://alphr.com.au/nfl/match/2025-r16-arizona-cardinals-v-atlanta-falcons

### Denver Broncos v Jacksonville Jaguars
Mon, 22 Dec, 08:05 am AEDT · Empower Field at Mile High · Week 16
Alphr AI win probability: Denver Broncos 66.4% / Jacksonville Jaguars 33.6%
- **Head to Head:** Denver Broncos to win @ $1.57 (edge +2.8%) — model probability 66.4% — result: LOST
- **Line / Spread:** Denver Broncos -3.5 @ $1.91 (edge +0.0%) — result: LOST
- **Total (Over/Under):** Over 46.5 @ $1.91 (edge +0.0%) — result: WON
- Predicted margin: Denver Broncos by 4 · Predicted total: 61
Full breakdown: https://alphr.com.au/nfl/match/2025-r16-denver-broncos-v-jacksonville-jaguars

### Detroit Lions v Pittsburgh Steelers
Mon, 22 Dec, 08:25 am AEDT · Ford Field · Week 16
Alphr AI win probability: Detroit Lions 77.5% / Pittsburgh Steelers 22.5%
- **Head to Head:** Detroit Lions to win @ $1.24 (edge -3.4%) — model probability 77.5% — result: LOST
- **Line / Spread:** Pittsburgh Steelers +7.5 @ $1.91 (edge +0.0%) — result: WON
- **Total (Over/Under):** Under 52.5 @ $1.91 (edge +0.0%) — result: LOST
- Predicted margin: Detroit Lions by 4 · Predicted total: 50
Full breakdown: https://alphr.com.au/nfl/match/2025-r16-detroit-lions-v-pittsburgh-steelers

### Houston Texans v Las Vegas Raiders
Mon, 22 Dec, 08:25 am AEDT · NRG Stadium · Week 16
Alphr AI win probability: Houston Texans 94.5% / Las Vegas Raiders 5.5%
- **Head to Head:** Houston Texans to win @ $1.06 (edge +0.4%) — model probability 94.5% — result: WON
- **Line / Spread:** Houston Texans -14.5 @ $1.91 (edge +0.0%) — result: LOST
- **Total (Over/Under):** Over 39.5 @ $1.91 (edge +0.0%) — result: WON
- Predicted margin: Houston Texans by 25 · Predicted total: 44
Full breakdown: https://alphr.com.au/nfl/match/2025-r16-houston-texans-v-las-vegas-raiders

### Baltimore Ravens v New England Patriots
Mon, 22 Dec, 12:20 pm AEDT · M&T Bank Stadium · Week 16
Alphr AI win probability: Baltimore Ravens 37.5% / New England Patriots 62.5%
- **Head to Head:** New England Patriots to win @ $2.54 (edge +23.2%) — model probability 62.5% — result: WON
- **Line / Spread:** New England Patriots +3.5 @ $1.91 (edge +0.0%) — result: WON
- **Total (Over/Under):** Over 48.5 @ $1.91 (edge +0.0%) — result: WON
- Predicted margin: Baltimore Ravens by 3 · Predicted total: 55
Full breakdown: https://alphr.com.au/nfl/match/2025-r16-baltimore-ravens-v-new-england-patriots

### Indianapolis Colts v San Francisco 49ers
Tue, 23 Dec, 12:15 pm AEDT · Lucas Oil Stadium · Week 16
Alphr AI win probability: Indianapolis Colts 12.7% / San Francisco 49ers 87.3%
- **Head to Head:** San Francisco 49ers to win @ $1.44 (edge +18.1%) — model probability 87.3% — result: WON
- **Line / Spread:** San Francisco 49ers -4.5 @ $1.91 (edge +0.0%) — result: WON
- **Total (Over/Under):** Under 46.5 @ $1.91 (edge +0.0%) — result: LOST
- Predicted margin: San Francisco 49ers by 11 · Predicted total: 44
Full breakdown: https://alphr.com.au/nfl/match/2025-r16-indianapolis-colts-v-san-francisco-49ers

## Model performance (2025)
_No settled predictions yet this season._

## More NFL predictions
- Previous round: https://alphr.com.au/nfl/2025/round/15 (markdown: /nfl/2025/round/15.md)
- Next round: https://alphr.com.au/nfl/2025/round/17 (markdown: /nfl/2025/round/17.md)
- All NFL rounds & tips: https://alphr.com.au/nfl (markdown: /nfl.md)

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All predictions are published before kick-off and verified after full time. Free, no login. 18+ gamble responsibly (AU).
Last updated: 2025-12-23 01:15 UTC (latest tip update)